A vaccine induced a neutral antibody response in adult volunteers and based on a Phase 1 clinical result the Eastern Equin encephalitis virus (EEEV), the Western Equin encephalitis virus (WEEV) and . Tests were conducted on 30 candidates.
Infected mosquito bites spread EEEV, WEEV and VEEV to humans. Horses are also susceptible to infection, but horses cannot transmit the virus directly to humans. Infections in humans are rare but can cause flu-like symptoms. In some cases, it can even lead to serious neurological damage or death.
The results of a clinical trial have been published in The Lancet Infectious Diseases.
The US National Institutes of Health said in a media release that a virus-like particle (VLP) vaccine candidate was designed as part of a study using proteins from the outer shell of the virus. VLPs cannot cause infection because they do not contain the genetic material needed to replicate the virus inside the cell.
Encephalitis is an infection of the active tissues of the brain caused by an infection that causes swelling of the brain. It can cause headaches, mental confusion, convulsions, stiff neck and sensitivity to light.
It hits 10 to 15 people per 100,000 people and can affect anyone. Encephalitis is a condition in which the body’s own immune response attacks the brain. The most common causes of viral encephalitis are herpes simplex viruses type 1 and 2, varicella zoster virus and enterovirus, which cause gastrointestinal illness.
Encephalitis can also be caused by ticks and other viruses carried by other insects or animals such as West Nile virus, Japanese encephalitis virus, La Cross virus, St. Louis virus, Equine virus, Powasan virus, Zika and Chikungunya. Other infectious microorganisms such as bacteria, fungi and parasites can also cause encephalitis.